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. Author manuscript; available in PMC: 2012 Mar 10.
Published in final edited form as: Neuroscience. 2010 Dec 16;176:152–161. doi: 10.1016/j.neuroscience.2010.12.008

Fig. 2.

Fig. 2

Potentiated ERK activation in the NAc, AMG and PFC in D3 receptor mutant mice compared to that in wild-type mice following CPP expression. Mice were given cocaine (Coc, 2.5 mg/kg) or saline (Sal) injections and were sacrificed at the end of the fourth CPP test. Western blotting was performed using brain samples from D3 receptor mutant (−/−) and wild-type (+/+) mice (n=7 mice each). Ratios of phospho-ERK (P-ERK) relative to total ERK protein levels in the NAc, AMG and PFC were analyzed. Data were expressed as mean± SEM relative to saline controls that were set as 1. Actin levels were used as a loading control. *p<0.05 compared with the saline control mouse group of the same genotype. #p<0.05 compared between the two genotypes.