Fig. 3.

EMT associated cell–cell junction and cell-adhesion/ECM changes, grouped by system and assembled by protein–protein contacts. Systems decreased or lost with EMT included tight junctions (TJ), adherens junctions (AJ), desmosomal junctions (DJ) and adhesion to basement membrane (BM). Systems increased with EMT included myosin motor coupling with intermediate filament and actin cytoskeletal assemblies, proteases responsible for BM degradation and extracellular matrix remodeling, and integrin/cadherin switching allowing new adhesion signals. Components in green were attenuated during EMT while those in light brown/red were increased with EMT