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. Author manuscript; available in PMC: 2011 Dec 15.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Oct 8;20(24):7525–7528. doi: 10.1016/j.bmcl.2010.09.115

Figure 3. Lack of stereoselectivityin lung metastasis of B16-F10 melanoma cells by R-3-CCPA, S-3-CCPA and Racemic -3-CCPA analogs in a mouse model.

Figure 3

A) Representative images show fixed intrathoracic organs including lung lobules with visiblenodules on the surfaces in black. Total numbers of nodules werereduced insamples treated with 7R, 7S or racemate compared to vehicle. Scale bar is 0.5 cm.

B) Lung nodules of B16-F10 melanoma cells were quantified. The number of lung nodules was significantly decreased in groups treated with R-3-CCPA, S-3-CCPA, and the Racemic-3-CCPA compared to vehicle. However, no statistically significant differences were found either between the stereoisomers or the racemate. Data represent the mean ± SEM, n = 6-8 mice. *p< 0.05 compared to vehicle analyzed by one-way ANOVA followed by Newman-Keuls multiple comparison test.