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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Mol Cell Neurosci. 2010 Dec 29;46(2):548–561. doi: 10.1016/j.mcn.2010.12.012

Figure 8. Genes with E2F binding sites are enriched in NPC clusters.

Figure 8

(A–C) Three E2F binding sites in the rVista database were over-represented in NPC clusters 6–9: E2F1/DP1, E2F4/DP1, and E2F4/DP2. Cluster numbers are indicated below the X of each plot. The Y axis indicates the mean number of binding sites per gene in each cluster. The first column (column A) is the calculation for all genes on Affymetrix chip. (D, E) Similar plots were generated for genes with binding sites for E2F4 (Conboy et al., 2007) and E2F1/E2F4/E2F6 (Xu et al., 2007) as detected by chromatin immunoprecipitation (ChIP). Note the enrichment of genes with E2F family binding sites in the NPC clusters using both informatics predictions (A–C) and direct ChIP analyses (D, E).