Aligned overlays of the coordinate sets used for the hydrodynamics calculations for maltose (top) and trehalose (bottom) which best matched the experiment D values. Hydroxyl O atoms are red, ring O5 atoms are orange, anomeric O atoms are yellow, and most water O atoms are transparent blue. For trehalose, the additional water molecules present due to the slightly more permissive value of Ecut are shown in bright blue (cyan). The sugars are oriented on the xy plane; waters with z > 0 (i.e., in front of the sugar) are omitted for clarity.