TABLE 3.
Biodistribution of 111In-IL-M1(50) (at 24 and 48 h after injection) in nude mice bearing both epithelioid (M28) and sarcomatoid (VAMT-1) subtypes of mesothelioma tumors (n=4). A control study performed using non-targeted 111In-CL is also shown (n=3). Data are %ID/g ± SD.
Organ |
111In-IL-M1(50) |
Control 111In-CL |
|
---|---|---|---|
24 h | 48 h | 48 h | |
Liver | 15.69±2.28 | 7.97±0.34 | 10.23±0.11 |
Heart | 0.57±0.13 | 0.19±0.13 | 0.31±0.11 |
Kidney | 2.26±1.24 | 1.17±2.75 | 1.40±0.51 |
Lung | 0.72±0.33 | 0.55±0.24 | 0.55±0.29 |
Spleen | 8.87±0.91 | 4.06.±086 | 5.04±0.89 |
Pancreas | 0.48±0.18 | 0.21±0.23 | 0.20±0.56 |
Stomach | 0.12±0.78 | 0.69±0.68 | 0.45±0.66 |
Sm. Int. | 0.74±0.89 | 0.41±0.98 | 0.47±0.91 |
Ig. Int. | 0.71±0.92 | 0.72±0.91 | 0.41±0.93 |
Muscle | 0.14±0.02 | 0.09±0.05 | 0.07±0.01 |
Fat | 0.23±0.01 | 0.21±0.03 | 0.10±0.02 |
Blood | 0.53±0.21 | 0.13±0.63 | 0.50±0.58 |
| |||
Tumor (M28) | 3.24±0.24 | 4.01±0.39 | 0.97±0.48 |
Tumor (VAMT-1) | 3.86±0.23 | 4.69±0.72 | 0.40±0.42 |