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. 2010 Oct 21;4:57–66. doi: 10.2174/1875397301004010057

Fig. (2).

Fig. (2)

Simulated 10 data points dose-response curve with actual ymax of 90.74%. ymax from Grid program is 64.00%. The difficulty in reproducing the actual ymax by the Grid program is due to the default constraint that the boundaries for ymax is between 0.0 and 1.2*maxY. In this special case, if we remove the constraint, the solution can be much closer to the actual values. For experimental data, however, this default constraint produces more reasonable solutions.