Table 2.

Body composition at ~8–10 weeks on study and body and muscle weights at sacrifice by experiment and treatment group.^*

Group	DXA data at ~8–10 wks on study					Weights at sacrifice
Experiment 1	N	Body Weight (g)	Fat (%)	BMD (mg/cm2) †	Lean mass(g)	N	Body weight (g)	Heart (g) †	Gastrocnemius (g) †
CON-TREX	22	27.4 ± 0.9	32.4 ± 2.0	48.5 ± 0.7	18.4 ± 0.7	19	36.5 ± 2.0	0.15 ± 0.01	0.10 ± 0.01
TREX1	20	24.6 ± 0.9	30.3 ± 2.1	51.6 ± 0.7§	17.0 ± 0.7	13	28.8 ± 2.2‡	0.16 ± 0.01	0.11 ± 0.01
TREX2	21	23.2 ± 0.9§	26.7 ± 2.1	52.0 ± 0.7§	16.8 ± 0.7	16	30.1 ± 1.5‡	0.17 ± 0.01	0.10 ± 0.01
Experiment 2
CON-WHL	18	24.9 ± 0.9	40.9 ± 1.9	48.9 ± 0.8	14.5 ± 0.2	16	35.3 ± 2.4	0.14 ± 0.01	0.08 ± 0.01
WHL	18	22.2 ± 0.6‡	29.3 ± 1.7§	51.5 ± 0.8‡	15.5 ± 0.3§	20	24.7 ± 0.8§	0.19 ± 0.01§	0.12 ± 0.01§

^*Only mice not censored from the survival analysis are included in the measurements of weight at sacrifice.

^†adjusted for total body mass

^‡p<0.05 vs. respective control group (using Tukey-Kramer adjustment for multiple comparisons in Treadmill experiment)

^§p<0.01 vs. respective control group (using Tukey -Kramer adjustment for multiple comparisons in Treadmill experiment)