Table 2.
Group | DXA data at ~8–10 wks on study | Weights at sacrifice | |||||||
---|---|---|---|---|---|---|---|---|---|
Experiment 1 | N | Body Weight (g) | Fat (%) | BMD (mg/cm2) † | Lean mass(g) | N | Body weight (g) | Heart (g) † | Gastrocnemius (g) † |
CON-TREX | 22 | 27.4 ± 0.9 | 32.4 ± 2.0 | 48.5 ± 0.7 | 18.4 ± 0.7 | 19 | 36.5 ± 2.0 | 0.15 ± 0.01 | 0.10 ± 0.01 |
TREX1 | 20 | 24.6 ± 0.9 | 30.3 ± 2.1 | 51.6 ± 0.7§ | 17.0 ± 0.7 | 13 | 28.8 ± 2.2‡ | 0.16 ± 0.01 | 0.11 ± 0.01 |
TREX2 | 21 | 23.2 ± 0.9§ | 26.7 ± 2.1 | 52.0 ± 0.7§ | 16.8 ± 0.7 | 16 | 30.1 ± 1.5‡ | 0.17 ± 0.01 | 0.10 ± 0.01 |
Experiment 2 | |||||||||
CON-WHL | 18 | 24.9 ± 0.9 | 40.9 ± 1.9 | 48.9 ± 0.8 | 14.5 ± 0.2 | 16 | 35.3 ± 2.4 | 0.14 ± 0.01 | 0.08 ± 0.01 |
WHL | 18 | 22.2 ± 0.6‡ | 29.3 ± 1.7§ | 51.5 ± 0.8‡ | 15.5 ± 0.3§ | 20 | 24.7 ± 0.8§ | 0.19 ± 0.01§ | 0.12 ± 0.01§ |
Only mice not censored from the survival analysis are included in the measurements of weight at sacrifice.
adjusted for total body mass
p<0.05 vs. respective control group (using Tukey-Kramer adjustment for multiple comparisons in Treadmill experiment)
p<0.01 vs. respective control group (using Tukey -Kramer adjustment for multiple comparisons in Treadmill experiment)