Table 1.

Covariates contributing to tacrolimus pharmacokinetic variability

Covariates	Reference
Transplanted organ	[15, 19, 37]
Patient age	[26, 27]
Patient race	[28–30]
Hepatitis C status	[21, 22]
Diabetes status	[36]
Time from transplantation	[24, 25]
Diurnal rhythm	[24, 31]
Food administration	[32, 33]
Corticosteroid dosage	[12, 13, 24]
Co-medication use	[3, 24]
Diarrhoea	[34, 35]
Albumin concentration	[24]
Haematocrit	[24]
Liver dysfunction	[15–18, 20]
Cytochrome P450 isoenzyme and P-glycoprotein genotype and phenotype	[6–11, 14]