. 2011 Feb;71(2):224–231. doi: 10.1111/j.1365-2125.2010.03825.x

Table 4.

Precision and bias calculated according to the methods of Sheiner & Beal comparing different estimates of renal function with gentamicin clearance in frail, non frail and all participants

Renal function estimate	ME (95% CI)	%ME (95% CI)	RMSE (95% CI)	r²
CG_ABW
Frail	−10.12 (−14.62, −5.63)	−21.25 (−29.36, −13.14)	12.60 (−90.91, 116.11)	0.82
Non frail	−10.18 (−15.73, −4.63)	−18.40 (−27.81, −8.98)	14.60 (−131.24, 160.42)	0.54
Combined	−10.15 (−13.60, −6.71)	−19.69 (−25.67, −13.70)	13.73 (−74.30, 101.77)	0.69
CG_IBW
Frail	1.12 (−1.17, 3.42)	2.26 (−2.84, 7.36)	4.00 (−10.57, 18.55	0.87
Non frail	−1.20 (−5.63, 3.24)	−2.52 (−10.46, 5.42)	8.45 (−91.29, 108.20)	0.62
Combined	−0.15 (−2.67, 2.39)	−0.36 (−5.10, 4.38)	6.81 (−46.52, 60.14)	0.76
CG_LBW
Frail	5.75 (3.38, 8.11)	12.54 (7.49, 17.60)	6.97 (−22.10, 36.04)	0.86
Non frail	7.19 (3.11, 11.27)	11.80 (5.42, 18.18)	10.54 (−71.83, 92.90)	0.61
Combined	6.54 (4.18, 8.90)	12.14 (8.20, 16.08)	9.10 (−36.98, 55.18)	0.76
eGFR (MDRD)
Frail	−19.24 (−23.06, −15.42)	−41.98 (−50.63, −33.33)	20.27 (−126.04, 166.57)	0.82
Non frail	−18.55 (−24.71, −12.38)	−32.87 (−44.14, −21.60)	21.89 (−273.75, 317.54)	0.56
Combined	−18.86 (−22.45, −15.27)	−36.98 (−44.09, −29.88)	21.17 (−145.05, 187.40)	0.68

ME, Mean Error (ml min⁻¹), a measure of bias; %ME, Mean Error (bias) expressed as a percentage of optimized gentamicin clearance; RMSE, Root Mean Square Error (ml min⁻¹), a measure of precision; CG_IBW, Cockcroft Gault estimate of creatinine clearance calculated using ideal bodyweight; CG_ABW; Cockcroft Gault estimate of creatinine clearance calculated using actual bodyweight; CG_LBW; Cockcroft Gault estimate of creatinine clearance calculated using lean bodyweight; eGFR(MDRD), estimated glomerular filtration rate calculated using the Modified Diet in Renal Disease equation normalized for body surface area (ml min⁻¹).