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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Nat Neurosci. 2010 Dec 19;14(1):19–21. doi: 10.1038/nn.2719

Fig. 2. hPSD sequence conservation.

Fig. 2

a. Cumulative frequency plot of dN/dS values for hPSD and non–PSD genes expressed in cortical neurons9, and human genome. hPSD neuronal genes are more constrained than non–PSD neuronal genes (p < 10−11).

b. Median mouse–human dN/dS shown for hPSD and subcellular structures expressed in cortical neurons9. Significance: p < 0.05 (*), p< 0.001 (***).

c, Boxplots of dN/dS distribution in hPSD hub proteins (>15 interactions, n = 23), non–hubs (≤15 interactions, n = 725) and the tandem affinity purification of PSD–95 complex14.