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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: RNA Biol. 2010 May–Jun;7(3):373–380. doi: 10.4161/rna.7.3.11693

Figure 3.

Figure 3

As was the case for miR-124, putative miR-128 and miR-320 putative targets tend to have sequences corresponding to nucleotides #2–7 in the 3′UTR. However, the tendency for these two miRNAs is much less strong (p < 10−5 versus p < 10−11). Moreover, unlike miR-124, both miR-128 and miR-320 have a tendency—albeit far weaker than the 5′ seed—for the 3′ sequences of the miRNAs to have possible effects (enrichment of complementary 6mers in putative targets). Since the current study was limited to studying 6mer seeds, these data do not test whether sequence determinants with fewer hybridizing nucleotides (5mers and smaller) may be more important in the case of these other miRNAs.