Table 3. Association of GRS with SLE subphenotypes.

	Continuous GRS			GRS High-Low Tertiles
	N	OR* (95% CI)	p-value*	N	OR (95% CI)	p-value
anti-dsDNA antibodies	1533	1.10 (1.07–1.13)	9.3E–12	1061	2.36 (1.76–3.16)	9.4E–09
immunologic disorder	1536	1.09 (1.06–1.13)	4.4E–09	1063	2.23 (1.64–3.03)	3.1E–07
oral ulcers	1533	0.95 (0.92–0.97)	5.0E–05	1061	0.62 (0.46–0.83)	0.0012
renal disorder	1541	1.06 (1.02–1.09)	0.00036	1067	1.47 (1.06–2.06)	0.023
hematologic disorder	1535	1.06 (1.03–1.09)	4.3E–05	1062	1.38 (1.03–1.84)	0.031
age at diagnosis<34 years	1753	1.06 (1.03–1.08)	8.1E–06	1219	1.45 (1.11–1.90)	0.0060
		β† (95% CI)			β† (95% CI)
age at diagnosis (continuous)	1753	−0.39 (−0.55–0.24)	8.6E–07	1219	−2.68 (−4.42–0.94)	2.6E–03

*Per unit GRS using logistic regression, adjusted for first 4 PCs, sex, and study source; adjusted for disease duration except age at diagnosis<34 years.

†: Per unit GRS using linear regression, adjusted for first 4 PCs, sex, and study source.