Table 5. Significance of SNPs in CUGBP2 in prediction of disease risk.

		CCall APOE ε4/ε4 stratum		Caribbean Hispanic+WU+ADNI				CCun+Hispanic+WU+ADNI
SNP	Allelea	Nb	Pc	Nb	ORd	95% CI	Pe	Nb	ORd	95% CI	Pe
rs11256915	A	408	0.286	1435	1.25	0.95–1.68	0.125	2382	1.43	1.13–1.83	3.3×10−3
rs2146551	A	407	0.055	1447	1.16	0.86–1.56	0.331	2393	1.35	1.05–1.73	0.018
rs731229	G	408	0.140	1444	1.16	0.83–1.62	0.378	2390	1.22	0.93–1.60	0.142
rs992193	A	408	0.313	1446	1.12	0.84–1.52	0.439	2391	1.20	0.95–1.53	0.118
rs2146553	G	408	0.033	1445	0.83	0.60–1.15	0.259	2392	0.81	0.63–1.05	0.106
rs10795839	G	408	0.488	1435	0.86	0.3–1.18	0.361	2382	0.86	0.66–1.14	0.305
rs1928724	A	407	0.698	1447	0.93	0.69–1.26	0.646	2394	0.94	0.72–1.23	0.655
rs1928722	A	408	0.789	1434	0.89	0.65–1.23	0.493	2381	0.88	0.66–1.16	0.371
rs201070	A	408	0.201	1446	0.96	0.71–1.29	0.793	2392	1.11	0.87–1.41	0.406
rs201071	A	407	0.018	1447	1.19	0.79–1.81	0.403	2394	1.49	1.06–2.11	0.022
rs201074	A	408	4.5×10−3	1433	0.69	0.48–1.00	0.052	2380	0.68	0.52–0.91	7.9×10−3
rs62209	C	402	3.8×10−3	1439	1.75	1.27–2.41	5.6×10−4	2371	2.04	1.56–2.67	1.6×10−7
rs201082	G	408	0.096	1435	1.61	1.14–2.29	7.5×10−3	2382	1.79	1.35–2.38	5.1×10−5
rs201097	A	408	0.509	1447	0.83	0.43–1.58	0.561	2394	0.75	0.46–1.22	0.248
rs201099	A	408	8.3×10−8	1447	1.56	1.12–2.18	9.1×10−3	2393	1.92	1.47–2.56	3.4×10−6
rs201100	G	408	0.019	1433	0.65	0.45–0.95	0.024	2380	0.68	0.52–0.89	4.9×10−3
rs201119	A	408	1.5×10−8	1447	1.43	1.00–2.03	0.048	2394	2.08	1.53–2.79	2.1×10−6
rs201124	A	408	1.3×10−6	1423	1.43	1.00–2.06	0.048	2370	1.82	1.34–2.46	1.2×10−4
rs7099713	A	408	2.3×10−4	1435	1.16	0.65–2.06	0.618	2381	1.45	0.94–2.22	0.096
rs1547221	G	408	4.4×10−5	1447	1.43	0.88–2.31	0.153	2394	1.82	1.24–2.64	1.9×10−3
rs913918	A	408	0.565	1434	1.47	1.04–2.09	0.029	2380	1.47	1.11–1.98	7.8×10−3
rs11256951	G	408	0.154	1435	0.95	0.70–1.28	0.740	2382	1.06	0.84–1.36	0.604
rs1999207	A	408	0.914	1447	0.92	0.67–1.24	0.568	2394	0.88	0.69–1.15	0.361
rs932918	A	407	0.908	1447	1.22	0.85–1.74	0.279	2392	1.12	0.84–1.50	0.420

^aAllele depicted is the allele with higher frequency in the APOE ε4/ε4 cases than ε4/ε4 controls, as denoted on the Illumina TOP strand.

^bSample size.

^cP-value for relationship-corrected chi-square test of allele frequency differences.

^dInteraction odds ratio with respect to allele noted based on logistic regression model.

^eP-value for interaction coefficient of logistic model.