Table 4.
List of proteins that were changed less than 1.5-fold in the lesion center of the injured spinal cord from the subacute (day 14) SCI group when compared to that detected in the acute (day 1) SCI group.
| no. | function | protein name | protein ID | 14d_mean (SEM) | 1d_mean (SEM) | p value | Mw/pI | score |
|---|---|---|---|---|---|---|---|---|
| 128 | actin binding | WD repeat-containing protein 1 | WDR1 | 0.036 (0.035) |
0.034 (0.017) |
0.980 | 66824/6.15 | 76 |
| 80 | acute phase | T-kininogen 2 | KNT2 | 0.648 (0.352) |
0.950 (0.085) |
0.481 | 48757/5.94 | 102 |
| 81 | acute phase | T-kininogen 1 | KNT1 | 0.270 (0.040) |
0.202 (0.055) |
0.353 | 48828/6.08 | 144 |
| 87 | cytoskeleton | Glial fibrillary acidic protein | GFAP | 0.458 (0.093) |
0.535 (0.036) |
0.469 | 49927/5.35 | 144 |
| 16 | metabolism | Bifunctional purine biosynthesis protein PURH | PUR9 | 0.039 (0.009) |
0.056 (0.055) |
0.629 | 64681/6.69 | 70 |
| 18~20 | metabolism | Pyruvate kinase isozymes M1/M2 | KPYM | 0.719 (0.280) |
0.864 (0.433) |
0.778 | 58294/6.63 | 134 |
| 24 | metabolism | Gamma-enolase | ENOG | 0.343 (0.130) |
0.446 (0.114) |
0.581 | 47111/5.03 | 155 |
| 25 | metabolism | Creatine kinase B-type | KCRB | 0.996 (0.226) |
0.767 (0.177) |
0.469 | 42983/5.30 | 151 |
| 26~28 | metabolism | Alpha-enolase | ENOA | 0.714 (0.271) |
1.040 (0.364) |
0.486 | 47440/6.16 | 185 |
| 32 | metabolism | 3-ketoacyl-CoA thiolase, mitochondrial | THIM | 0.133 (0.040) |
0.153 (0.061) |
0.782 | 42244/8.09 | 137 |
| 36,37 | metabolism | Glutamine synthetase | GLNA | 0.338 (0.096) |
0.249 (0.080) |
0.505 | 42982/6.64 | 179 |
| 47~49 | metabolism | Glyceraldehyde-3-phosphate dehydrogenase GAPDH | G3P | 2.351 (0.603) |
3.215 (1.492) |
0.577 | 36090/8.14 | 88 |
| 68,70, 71 | metabolism | Triosephosphate isomerase | TPIS | 0.609 (0.219) |
0.413 (0.134) |
0.461 | 27345/6.89 | 164 |
| 36,37 | metabolism | Glutamine synthetase | GLNA | 0.338 (0.096) |
0.249 (0.080) |
0.505 | 42982/6.64 | 179 |
| 111 | metabolism | Malate dehydrogenase, mitochondrial | MDHM | 0.874 (0.241) |
0.726 (0.240) |
0.682 | 36117/8.93 | 217 |
| 123 | metabolism | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | ODPB | 0.103 (0.059) |
0.070 (0.002) |
0.636 | 38957/6.20 | 100 |
| 125, 126 | metabolism | Transketolase | TKT | 0.143 (0.047) |
0.147 (0.081) |
0.970 | 67601/7.23 | 92 |
| 103 | microtubule | Tubulin alpha-1C chain | TBA1C | 0.132 (0.049) |
0.098 (0.021) |
0.559 | 49905/4.96 | 64 |
| 112 | microtubule | Tubulin beta-2C chain | TBB2C | 1.464 (0.416) |
1.289 (0.343) |
0.764 | 50225/4.79 | 210 |
| 43 | oxidoreduction | Alcohol dehydrogenase [NADP+] | AK1A1 | 0.153 (0.030) |
0.135 (0.105) |
0.860 | 36711/6.84 | 84 |
| 98 | oxidoreduction | Aldose reductase | ALDR | 0.128 (0.047) |
0.124 (0.042) |
0.956 | 35774/6.26 | 101 |
| 116~ 118 | oxidoreduction | Glutamate dehydrogenase 1, mitochondrial | DHE3 | 0.286 (0.100) |
0.410 (0.233) |
0.613 | 61719/8.05 | 172 |
| 86 | protease inhibitor | Serine protease inhibitor A3N | SPA3N | 0.751 (0.144) |
0.748 (0.369) |
0.995 | 46622/5.33 | 109 |
| 23 | proteolysis | Cytosolic non-specific dipeptidase | CNDP2 | 0.174 (0.029) |
0.176 (0.083) |
0.983 | 53116/5.43 | 120 |
| 34 | proteolysis | Aminoacylase-1A | ACY1A | 0.058 (0.014) |
0.074 (0.031) |
0.628 | 46060/6.03 | 77 |
| 104 | secreted glycoprotein | Alpha-1B-glycoprotein | A1BG | 0.197 (0.070) |
0.211 (0.104) |
0.914 | 57127/6.89 | 76 |
| 84,85 | signal transduction | Rab GDP dissociation inhibitor alpha | GDIA | 0.403 (0.118) |
0.440 (0.112) |
0.829 | 50504/5.00 | 73 |
| 122 | stress response | Heat shock-related 70 kDa protein 2 | HSP72 | 0.084 (0.031) |
0.100 (0.024) |
0.738 | 69599/5.51 | 115 |
| 4,5 | transport | Serum albumin | ALBU | 3.629 (1.939) |
4.722 (1.882) |
0.722 | 70682/6.09 | 306 |
| 40 | transport | Aspartate aminotransferase | AATM | 0.246 (0.070) |
0.165 (0.041) |
0.387 | 47683/9.13 | 64 |
| 55 | transport | 3-mercaptopyruvate sulfurtransferase | THTM | 0.053 (0.014) |
0.047 (0.046) |
0.893 | 33205/5.88 | 75 |
| 108 | transport | Clathrin light chain B | CLCB | 0.310 (0.090) |
0.324 (0.156) |
0.953 | 25216/4.65 | 63 |
| 127 | transport | V-type proton ATPase catalytic subunit A | VATA | 0.056 (0.028) |
0.057 (0.027) |
0.982 | 68283/5.42 | 77 |