Table 7.
Cytokine levels (in pg/ml, median and range) without antigenic stimulus and after stimulation with BCG and PHA in the supernatant of cord blood cell cultures
| Non-exposed newborns | HIV-exposed newborns | p value | |
|---|---|---|---|
| IL-2 non-stimulated | 0.0 (0 -76) | 0.72 (0 - 81) | 0.13 |
| BCG | 0.0 (0 -78) | 0.36 (0 - 79) | 0.54 |
| PHA | 43.7 (0 - 1278) | 18.9 (0 - 5936) | 0.46 |
| IL-4 non-stimulated | 39.2 (39 - 76) | 25.5 (10 - 76) | <0.005 |
| BCG | 39.4 (40 - 76) | 25.6 (9 - 76) | <0.005 |
| PHA | 39.2 (39 - 78) | 26.7 (9.5 - 76) | <0.005 |
| IL-7 non-stimulated | 66.0 (0 - 87) | 0.0 (0 - 87) | 0.13 |
| BCG | 66.4 (0 - 87) | 1.5 (0 - 93) | 0.24 |
| PHA | 66.5 (0 - 87) | 0.0 (0.0 - 88) | 0.11 |
| IL-10 non-stimulated | 0 (0 - 88) | 3.5 (0 - 1028) | 0.13 |
| BCG | 199 (0 - 1522) | 582 (0 - 7049) | 0.06 |
| PHA | 224 (0 - 1934) | 410 (0 - 36093) | 0.19 |
| IL-12 non-stimulated | 0.66 (0 - 13.3) | 0.24 (0 - 5.7) | 0.41 |
| BCG | 0.83 (0 - 26) | 0.74 (0 - 3.64) | 0.10 |
| PHA | 0.62 (0 - 3) | 1.1 (0 - 8) | 0.58 |
| IFNγ non-stimulated | 0.0 (0 - 66) | 17.5 (0 - 194) | 0.01 |
| BCG | 0.0 (0 - 1188) | 19.4 (0 - 550) | 0.02 |
| PHA | 24.3 (0 - 2445) | 73.2 (0 - 2928) | 0.28 |
| TNFα non-stimulated | 136.4 (0 - 500) | 181.6 (0 - 3381) | 0.66 |
| BCG | 1458.1 (138 - 7026) | 1069.0 (283 -14724) | 0.96 |
| PHA | 535.0 (298 - 5672) | 658.4 (0 - 6313) | 0.63 |