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| IC50 (µM) | ||
| MAEC | BAEC | |
| emodin | 32±11 | 39±9 |
| coleon AL | 30±5 | 31±13 |
| wortmannin | 55±5 | 29±12 |
| LY294002 | 7±2 | 3±1 |
| SU5416 | 29±2 | 8±2 |
IC50 values (± SD) for emodin and coleon A lactone are shown for the inhibition of proliferation of both bovine aortic endothelial cells (BAEC) and mouse aortic endothelial cells (MAEC). For comparison, effects of 3 other anti-angiogenic compounds are shown (wortmannin, LY294002, and SU5416).
