Table 3.
Subjects fasting biochemical parameters according to MTTP−493 G/T polymorphism at entry on a Western diet (WD)
| G/G (n = 30) | G/T (n = 30) | T/T (n = 9) | P valuea | |
|---|---|---|---|---|
| Cholestanolb | 129.6 ± 9.8 | 136.4 ± 11.3 | 199.0 ± 30.0 | 0.034 |
| Sitosterolb | 103.8 ± 12.5 | 114.1 ± 15.5 | 261.1 ± 104.7 | 0.037 |
| Desmosterolb | 114.2 ± 6.9 | 106.1 ± 5.7 | 109.2 ± 4.2 | ns |
| Lathosterolb | 152.8 ± 15.2 | 142.3 ± 10.3 | 188.7 ± 21.8 | 0.081 |
| Cholesterol (mmol/l) | 6.62 ± 0.14 | 6.64 ± 0.19 | 7.37 ± 0.22 | 0.106 |
| HDL cholesterol (mmol/l) | 1.68 ± 0.09 | 1.65 ± 0.09 | 1.65 ± 0.19 | ns |
| LDL cholesterol (mmol/l) | 4.26 ± 0.17 | 4.25 ± 0.19 | 4.81 ± 0.22 | ns |
| TRL cholesterol (mmol/l) | 0.92 ± 0.12 | 0.98 ± 0.11 | 1.37 ± 0.31 | ns |
| ApoB-cholesterol (mmol/l) | 5.18 ± 0.22 | 5.15 ± 0.24 | 6.07 ± 0.47 | ns |
| TRL TG (mmol/l) | 0.87 ± 0.11 | 0.85 ± 0.11 | 0.86 ± 0.17 | ns |
| TRL PL (mmol/l) | 0.29 ± 0.03 | 0.30 ± 0.03 | 0.33 ± 0.06 | ns |
| ApoB (g/l) | 1.22 ± 0.05 | 1.33 ± 0.03 | 1.21 ± 0.09 | ns |
| Insulin (μU/ml) | 11.23 ± 1.29 | 9.21 ± 1.15 | 8.78 ± 1.66 | ns |
Values are mean ± SEM. ApoB-cholesterol is the calculated sum of apoB-containing LDL and TRL-cholesterol levels
a Comparison between genotypes at entry tested with general linear models and adjusted for age, menopausal status and BMI. ns non-significant (P ≥ 0.05)
b 102 mmol/mol cholesterol