Table 2.
mRNA microarray studies on human meningiomas identified with our search strategy
| Year | Author | Microarray platform | No. of transcripts | No. of meningiomas | Distribution WHO grades | Source of control | No. of controls | Main results | Selected interesting molecules or pathways |
|---|---|---|---|---|---|---|---|---|---|
| 2002 | Watson et al. [14] | Affymetrix HCG110 | 2,059 | 15 | 6 grade I | Meninges | 3 | Gene expression profiles associated with WHO grade subtypes | Growth hormone receptors, endothelin receptor A, IGF2, IGFBP-7 |
| 6 grade II | |||||||||
| 3 grade III | |||||||||
| 2003 | Sasaki et al. [15] | Affymetrix U95A | 12,000 | 3 | 1 grade I | Primary cultures of the samples | 3 | Differing transcriptomic profiles between original frozen meningioma samples and primary cultures | Wnt, Notch, PI3K, MAP kinase |
| 1 grade II | |||||||||
| 1 grade III | |||||||||
| 2003 | Fathallah-Shaykh et al. [16] | 19 K gene microarrays (Ontario Cancer Institute) | 19,200 | 10 | Not declared | Human brain | 4 | Differential gene expression between meningiomas and control human brain | PRKDC, PSIP2, NCOR2, TAF13 |
| 2005 | Wrobel et al. [17] | Custom made cDNA microarray | 4,211 | 30 | 3 grade I1 | Human RNA pool | Pool of 8 different tissues | Meningioma signature genes and differences in gene expression according to WHO grade | PTGDS, CLU, BAD, MGP, LIG1, ANXA2, MMP12, VIM, TIMP1, CCND1 |
| 12 grade II | |||||||||
| 5 grade III | |||||||||
| 2005 | Lusis et al. [18] | Affymetrix U133A and U133B | 39,000 | 10 | Not declared | – | – | Loss of transcripts in grade III meningiomas | NDRG2 |
| 2006 | Sayagues et al. [19] | Affymetrix U133A | 18,400 | 7 spinal and 11 intracranial | Only WHO grade I | – | – | Differential gene expression between intracranial and spinal meningiomas | NR4A3, DUSP5, HOXA5 |
| 2007 | Carvalho et al. [20] | Affymetrix U133 Plus 2.0 | 47,400 | 23 | 8 grade I | – | – | Differential gene expression between grade I and III meningiomas | TGF-ß signaling pathway |
| 7 grade II | |||||||||
| 8 grade III | |||||||||
| 2008 | Aarhus et al. [21] | Applied Biosystems 1700 | 30,000 | 27 | 22 grade I | Arachnoid cyst membranes | 4 | Differential gene expression between arachnoidal cells and meningiomas, and between meningothelial and fibrous meningiomas. | WWOX, TYMS, BMPR1B, RAMP1, DMD |
| 5 grade II | |||||||||
| 2008 | Lillehei et al. [22] | Affymetrix U133 Plus 2.0 | 47,400 | 5 radiation induced and 6 sporadic | Not declared | Pediatric nervous system tumors | 62 | Differential gene expression between sporadic and radiation-induced meningiomas | RGS3, ZNF564, GYPA, CRHR1, MST1R, INPP5B |
| 2008 | Hankins et al. [23] | Affymetrix U95A | 12,000 | 6 | 6 grade I | Dura | 4 | Differential gene expression between meningiomas and dura | DLC1 |
| 2008 | Claus et al. [24] | Affymetrix U133 plus 2.0 | 47,400 | 31 | 31 grade I | – | – | Differential gene expression between progesterone receptor positive and negative meningiomas | SLC24A3, SERPINB1, PDGFRB, MAP4K4, FAT4 |
| 2009 | Fevre-Montange et al. [25] | CodeLink Uniset Human Whole Genome Bioarrays | 55,000 | 17 | 10 grade I | Human brain | 1 | Differential gene expression between fibrous and meningothelial meningiomas, and between WHO grades | CD44, LOX, CKS2, BIRC5, Notch1, MMP2, TIMP3, FAT3 |
| 6 grade II | |||||||||
| 7 grade III | |||||||||
| 2009 | Castells et al. [26] | The human CNIO oncochip 12 K cDNA microarray | 11,500 | 18 | 18 grade I | GBMa | 17 | Automated prediction of brain tumor biopsies | GFAP, DSP |
GBM glioblastoma multiforme