Figure 7.
Reducing Mcl-1 expression in Panc-1 and A549 cells sensitizes them to ABT-737 treatment. (A) Mcl-1 protein expression was reduced by siRNA in panc-1 and A549 cells. Cell lysates of 1 × 105 panc-1 or A549 cells were examined by western blot. (B) Panc-1 or A549 cells with different expression levels of Mcl-1 were treated with the indicated concentrations of ABT-737 and cell viability was measured by PI staining 72 hours after treatment for panc-1 cells or 48 hours for A549 cells. Data represent mean ± standard deviation of triplicate experiments and have been repeated three times independently.