TABLE 5.
Comp. | Group | R1 | R2 | Mean number of writhings ±SEM | % Protection |
---|---|---|---|---|---|
Control | I | ---- | ---- | 42.15±3.16 | ---- |
Aspirin | II | ---- | ---- | 12.20±1.50 | 71.00 |
7a | III | H | H | 18.23±2.18 | 56.74 |
7b | IV | H | 4-OCH3 | 15.31±1.96 | 63.67 |
7c | V | H | 4-OH | 17.84±2.14 | 57.67 |
7d | VI | H | 4-Cl | 14.78±1.83 | 64.93 |
7e | VII | H | 4-NO2 | 16.43±2.02 | 61.07 |
Acetic acid-induced writhing method, Tween-80 (0.1%, 0.5 ml) used as control, aspirin used as standard, concentration of drug used 100 mg/kg in 0.1% Tween-80 suspension, Number of animals used in each group 6