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. 2008 Nov-Dec;70(6):733–739. doi: 10.4103/0250-474X.49094

TABLE 3.

PERMEATION PARAMETERS OF OXYBUTYNIN ACROSS RABBIT EAR SKIN

Formulation Flux (mg/cm2.h) Intercept R2 *Q24 (mg/cm2)
F1 0.0095 0.0178 0.9655 0.2312
F2 0.0264 0.1205 0.9608 0.6405
F3 0.0244 0.0223 0.9494 0.5469
*

Amount of drug released per unit surface area after 24 h. Formulations F1 and F3 showed zero order kinetic model while formulation F2 showed root time kinetics with R2 value of 0.9608. [Formulations F2 and F3 (containing film formers and penetration enhancers) showed more flux and Q24 value for the drug as compared to Formulation F1].