Scheme 1.
synthesis of isatinsulphonamide derivatives
For SPIII-S, R is H, R1 is H and R2 is H; for SPIII-SMe, R is CH3, R1 is H and R2 is H; for SPIII-SCl, R is Cl, R1 is H and R2 is H; for SPIII-SM, R is Cl, R1 is H and R2 is 4,5-dimethyl-2-isoxazolyl; for SPIII-5Br-AC, R is Br, R1 is COCH3 and R2 is 4,6-dimethyl-2-pyrimidinyl; for SPIII-5Br-BZ, R is Br, R1 is COC6H5 and R2 is 4,6-dimethyl-2-pyrimidinyl; for SPIII-5Me-AC, R is CH3, R1 is COCH3 and R2 is 4,6-dimethyl-2-pyrimidinyl and for SPIII-5Cl-BZ, R is Cl, R1 is COC6H5 and R2 is 4,6-dimethyl-2-pyrimidinyl