TABLE 1.
EFFECTS OF WITHANIA ROOT EXTRACT AND ITS INTERACTION WITH GABAERGIC MODULATORS ON SLEEP-WAKE CYCLE OF SLEEP-DISTURBED RATS
| Drug treatment (mg/kg) | Sleep Latency (Mean±SEM) | Slow Wave Sleep (Mean±SEM) | REM (Mean±SEM) | Total sleep time (Mean±SEM) | Total Waking (Mean±SEM) |
|---|---|---|---|---|---|
| Naïve | 12.8±2.8 | 140.4±4.8 | 10.9±1.6 | 151.3±5.9 | 88.7±5.8 |
| Control | 28.1±2.2a | 88.2±5.7a | 4.8±0.8a | 93.0±5.9a | 147.0±4.8a |
| Ash (100) | 15.4±2.2b | 160.7±5.9b | 3.0±1.2b | 163.7±5.2b | 76.3±5.2b |
| Dia (0.5) | 8.0±2.0b | 163.1±4.9b | 3.2±0.4b | 166.3±4.6b | 73.7±4.7b |
| Flu (2) | 15.0±21 | 135.4±3.5 | 7.0±1.3 | 142.4±3.5 | 97.5±3.6 |
| PTX (2) | 240.0±0.0 | 0.0±0.0 | 0.0±0.0 | 0.0±0.0 | 240.0±0.0 |
| Mus (0.05) | 10.0±2.1b | 180.0±3.1b | 3.8±2.9b | 183.8 ± 4.0b | 56.2±4.0b |
| Ash (100)+ Dia (0.5) | 8.4±3.6ns | 174.3±7.7ns | 2.5±0.6ns | 176.8±7.4ns | 63.2±7.4ns |
| Ash (100)+ Flu (2) | 17.2±3.7b | 170.2±4.5b | 3.0± 4.2 | 173.2±4.3b | 66.8±4.5b |
| Ash (100) +PTX (2) | 38.1±4.0b,c | 76.4±6.7b,c | 4.4±1.1b,c | 80.8±7.4b,c | 159.2±6.8b,c |
| Ash (100)+Mus (0.05) | 5.0±2.0b,d | 220.0±3.0b,d | 2.1±3.5b,d | 222.1±2.9b,d | 17.9±2.8b,d |
Values are expressed Mean±SEM.
a
P<0.05 as compared to naïve (without sleep deprived).
b
P<0.05 as compared to control (sleep-deprived).
c
P<0.05 as compared to PTX (2)
d
P<0.05 as compared to Mus (0.05)
ns
Not Significant (ANOVA followed by Tukey test)