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. 2010 Jul 15;10(2):198–208. doi: 10.4161/cbt.10.2.12193

Figure 6.

Figure 6

MMP inhibition downregulates Wnt-induced MMP-3 expression. (A) Casein zymography (top) and western blot (bottom) of conditioned media obtained from C57MG and C57MG/Wnt1 cells cultured for four days in the absence or presence of AG3340 or rTIMP-2 at indicated concentrations. Recombinant MMP-3 was loaded as positive control. (B) MMP-3 promoter activity in C57MG and C57MG/Wnt1 cells from clone 1 and clone 2 treated with AG3340 (50 µg/ml). The data represent the mean FFL/RL ratio (±SD) from triplicate samples and are representative of four experiments showing similar results.