Fig. 3.

Deregulated pathways leading to leukemia. Although leukemias are heterogeneous in terms of phenotypes, there are general mechanisms underlying leukemic transformation such as increased cell survival, increased proliferation capacity, increased self-renewal capacity, genomic instability, and prevention of differentiation. Examples of such deregulated mechanisms and/or signaling pathways that have been found in various types of leukemias are indicated.