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. Author manuscript; available in PMC: 2011 Oct 8.
Published in final edited form as: Semin Cancer Biol. 2010 Oct 8;20(5):329–339. doi: 10.1016/j.semcancer.2010.10.002

Fig. 4.

Fig. 4

Inferred RECQ helicase substrates and their roles in DNA metabolism. The common model substrates depicted in Fig. 3 and used to define RECQ helicase biochemical activities have direct counterparts in cellular DNA metabolism. RECQ helicases are able to unwind and release DNA flaps (upper left); promote replication fork progression, regression or remodeling (lower left); release an invading 3′ DNA tail in a D-loop (upper right); and branch migrate and, in the case of BLM in conjunction with topoisomerase IIIα, resolve separate DNA duplexes joined in a Holiday junction (lower right).