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. Author manuscript; available in PMC: 2012 Feb 15.
Published in final edited form as: Dev Biol. 2010 Dec 10;350(2):405–413. doi: 10.1016/j.ydbio.2010.12.004

Figure 6.

Figure 6

Embryos raised at permissive temperature to dct+ stage, when shifted show no melanized cells. A) Wild-type embryo showing dct expression in retinal pigment epithelium (RPE) and neural crest melanoblasts, B) wild-type embryos 20 hours after upshift (stage equivalent to 45 hours at standard temperature) showing differentiated melanocytes, C) mitfafh53 embryo showing dct expression at time of temperature upshift, D) mitfafh53 embryos 20 hours after upshift do not display any melanized cells save for RPE. In A and C, embryos were treated with 0.2 mM PTU to suppress melanin synthesis.

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