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. 2010 Jun 4;21(3):501–509. doi: 10.1093/cercor/bhq093

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© The Authors 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 9. — Learning-facilitated plasticity is prevented by an antagonist of the NMDA receptor. Application of the NMDA receptor antagonist D-AP5 (n = 6, 19.7 μg) significantly prevents learning-facilitated plasticity compared to vehicle-injected controls (n = 6). Whereas presentation of a novel object-containing hole board during sub-LFS (1Hz, 600 pulses) facilitates robust LTD, when D-AP5 is given prior to stimulation, this facilitation is blocked completely. Analog traces show the field potentials preinjection, 5 min, 4 h, and 24 h following sub-LFS. Vertical scale bar corresponds to 3 mV, and horizontal bar corresponds to 3 ms.