Fig. 1.

Targeted deletion of Gpr124 results in profound CNS-specific vascular hemorrhage. Gpr124^Lz/Lz (KO) mutants displayed prominent hemorrhage in the ventral forebrain and along the spinal cord at E12.5 [arrowheads indicate hemorrhage in Gpr124^Lz/Lz mutants (B) and corresponding normal regions in heterozygous (Het) Gpr124^Lz/WT embryos (A)]. The hemorrhage extended throughout the forebrain of KO mutants at E15 (white arrowhead in D) and through to birth (P0) (yellow arrowheads in F). (Compare with corresponding normal regions in Het embryos in C and E). Stereotypic, large superficial vessels of the head and forelimb had the same normal appearance in KO mutants as in Het embryos (yellow arrowheads in C and D).