Table 2. Cre-mediated gene repair.
Genetic cross | No. of litters | Cre | aNumber genotyped (bnumber expected) | |||||
|
|
|
Hdh: +/+ |
+/– |
STOP/+ |
ΔSTOP/+ |
STOP/– |
ΔSTOP/– |
Hdh+/–; Cre/+ × HdhSTOP/+ | 8 | – | 9 (9) | 9 (9) | 8 (9) | NAc | 0 (9) | NA |
+ | 9 (9) | 11 (9) | NA | 9 (9) | NA | 7 (9) | ||
Hdh+/–; Cre/Cre × HdhSTOP/+ | 4 | + | 10 (10) | 9 (10) | NA | 11 (10) | NA | 9 (10) |
aAll progeny genotyped at P10.
bCalculated using the predicted Mendelian ratio.
cNA, not applicable.