Table 2.

Cellular origin of transcripts up- and down-regulated in the circulating leukocyte pool of chronically lonely individuals

	Mean cell diagnosticity score	Difference from genome-wide mean diagnosticity* (±SE)	t†	P
Genes up-regulated
Monocyte	−0.33	−0.14 ± 0.18	−0.79	0.7485
Dendritic cell	0.52	0.39 ± 0.15	2.69	0.0042
NK cell	0.48	−0.07 ± 0.15	−0.44	0.6704
CD4+ T cell	0.31	−0.01 ± 0.12	−0.12	0.5472
CD8+ T cell	0.32	0.15 ± 0.11	1.33	0.0926
B cell	−1.61	−0.35 ± 0.20	−1.77	0.9604
Genes down-regulated
Monocyte	0.26	0.45 ± 0.09	4.75	0.0001
Dendritic cell	0.82	0.70 ± 0.08	9.20	0.0001
NK cell	0.44	−0.11 ± 0.08	−1.39	0.9175
CD4+ T cell	−0.27	−0.59 ± 0.06	−9.52	0.9999
CD8+ T cell	−0.38	−0.54 ± 0.06	−9.30	0.9999
B cell	−1.09	0.17 ± 0.10	1.69	0.0459

Positive diagnosticity indicates that differentially expressed genes originate predominately from the analyzed cell type. Negative values are uninformative, implying that transcripts originate from other cell types or from the analyzed cell type as well as other cell types.

*Positive values imply that differentially expressed genes originate from the indicated cell type. Negative values are uninformative (transcripts originate from other cell types or from the indicated cell type as well as other cells).

^†Up-regulated df = 94, down-regulated df = 350.