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. Author manuscript; available in PMC: 2011 Feb 18.
Published in final edited form as: J Org Chem. 2009 Dec 18;74(24):9245–9264. doi: 10.1021/jo901767e

Table 6.

Summary for in vivo Biological Activities from Multivalent Ligand H-Tyr-d-Ala-Gly-Phe-Met-Pro-Leu-Trp-0-3′5′-Bzl(CF3)2

  1. ligand has potent antinocipetive effect in naïve rats

  2. potent antiallodynic effects in SNL rats

  3. potent antihyperalgesic effects in SNL rats

  4. no motor skill impairment in Rotarod Test

  5. no development of tolerance

  6. blocks substance P-induced flinching