Fig. 3.

Comparison of Gla-containing peptides from Conus species. The posttranslational modification of glutamate to γ-carboxyglutamate (Gla or γ) is shown, and a comparison of the sequences of four Gla-containing Conus venom peptides to the N-terminal sequence of human blood clotting factor IX is shown. Note that one Conus peptide, conantokin-G from C. geographus, has a Gla domain motif that has similar spacing to factor IX (see boxed sequences), whereas the three other Gla-containing peptides do not have an arrangement of Gla residues characteristic of a Gla domain. #, amidated C terminus; W, 6-bromotryptophan; T′, glycosylated threonine; γ, γ-carboxyglutmate; h-FIX, human factor IX.