Figure 1.

Coadministration of rHuPH20 with lispro (A) or RHI (B) accelerates insulin pharmacokinetics as assessed by serum insulin concentrations, which were assayed using a standard insulin radioimmunoassay (Millipore, St. Charles, MO) validated for both lispro and RHI, and improved postprandial glycemic response (C and D) to a standardized liquid test meal (12 oz standard-formula Ensure [Abbott Laboratories, Abbott Park, IL]; 60 g carbohydrates). Blood glucose levels were determined using a YSI STAT2300 glucose analyzer (YSI Incorporated, Yellow Springs, OH). Data shown are from efficacy-evaluable populations.