Table 3.
Difference in risk of type 2 diabetes per FTO A allele according to combinations of physical activity and caloric intake
| Inactive |
Active |
P* | |||
|---|---|---|---|---|---|
| High intake | Low intake | High intake | Low intake | ||
| N | 5,145 | 5,400 | 5,416 | 5,158 | __ |
| Type 2 diabetes, N (%) | 137 (2.7) | 175 (3.2) | 113 (2.1) | 108 (2.1) | |
| OR (95% CI) of type 2 diabetes per A allele† | 1.36 (1.07–1.73) | 1.20 (0.97–1.48) | 1.14 (0.87–1.48) | 1.33 (1.01–1.75) | 0.78 |
| P† | 0.01 | 0.10 | 0.35 | 0.04 | |
High intake, >1,679 kcal/day; low intake, ≤1,679 kcal/day; inactive, ≤8.8 MET-hours/week; active, >8.8 MET-hours/week.
*P indicates the significance of the interaction across the four categories defined by caloric intake and physical activity.
†Odds ratio (OR), 95% CI, and associated P value for likelihood of type 2 diabetes per A allele within each category of caloric intake and physical activity.