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. 2011 Feb;162(3):623–632. doi: 10.1111/j.1476-5381.2010.01057.x

Figure 2.

Figure 2

Anti-inflammatory effect of 15d-PGJ2-NC or unloaded 15d-PGJ2 under different inflammatory stimuli. The mice were treated with saline (0.2 mL, s.c.) or 15d-PGJ2-NC (3, 10 or 30 µg·kg−1, s.c.), and then injected i.p. with Cg at a dose of 500 µg per cavity (A), LPS at a dose of 100 ng per cavity (C), or mBSA challenge at a dose of 30 µg per cavity (E); sham immunized mice (FI) without the mBSA antigen were used as control. Another set of mice was treated with saline (0.2 mL, s.c.) or unloaded 15d-PGJ2 (3, 10 or 30 µg·kg−1, s.c.), and then injected i.p. with Cg at a dose of 500 µg per cavity (B), LPS at a dose of 100 ng per cavity (D), or mBSA challenge at a dose of 30 µg per cavity (F). Neutrophil migration was evaluated after 4 h. The values are means (±SD) of 6 animals per group. *P < 0.05 compared with carrageenan, LPS or mBSA group; #P < 0.05 compared with saline group (anova followed by Bonferroni's t-test).