Table 2.
Echocardiography of MI rats after treatment with scutellarin for 4 and 8 weeks
| Group | Normal (n = 8) | Scutellarin (30 mg kg−1 day−1n = 8) | Sham (n = 8) | MI (n = 8) | MI + Scu (3 mg kg−1 day−1n = 9) | MI + Scu (10 mg kg−1 day−1n = 9) | MI + Scu (30 mg kg−1 day−1n = 9) |
|---|---|---|---|---|---|---|---|
| 4 weeks | |||||||
| LVDd (mm) | 6.09 ± 0.21 | 6.17 ± 0.13 | 6.15 ± 0.17 | 9.35 ± 0.29## | 8.94 ± 0.66 | 8.57 ± 0.45 | 8.31 ± 0.23 |
| LVSd (mm) | 3.56 ± 0.17 | 3.67 ± 0.18 | 3.73 ± 0.14 | 8.01 ± 0.21## | 7.5 ± 0.59 | 6.87 ± 0.37 | 6.57 ± 0.33 |
| FS (%) | 40.2 ± 2.16 | 38.9 ± 1.87 | 39.5 ± 1.59 | 14.6 ± 1.13## | 16.3 ± 1.14 | 19.8 ± 1.54 | 22 ± 2.04* |
| EF (%) | 75.8 ± 2.21 | 74.3 ± 1.96 | 76.6 ± 1.65 | 27.7 ± 1.5## | 36.9 ± 1.36 | 43.5 ± 2.67** | 50.1 ± 3.66** |
| 8 weeks | |||||||
| LVDd (mm) | 6.49 ± 0.27 | 6.71 ± 0.18 | 6.58 ± 0.2 | 9.84 ± 0.32## | 9.67 ± 0.44 | 9.48 ± 0.45 | 8.9 ± 0.55 |
| LVSd (mm) | 4.04 ± 0.16 | 3.93 ± 0.23 | 3.9 ± 0.21 | 8.36 ± 0.15## | 8.17 ± 0.48 | 7.43 ± 0.27* | 6.92 ± 0.28** |
| FS (%) | 42.4 ± 2.01 | 43.5 ± 1.69 | 41.3 ± 1.07 | 15.1 ± 1.08## | 16.1 ± 1.48 | 20.5 ± 1.37 | 22.9 ± 1.73** |
| EF (%) | 77.5 ± 2.81 | 78.3 ± 1.49 | 79.4 ± 1.38 | 25.1 ± 1.06## | 32.3 ± 1.36 | 42 ± 2.91** | 48.9 ± 2.49** |
##
P < 0.01 versus sham
*
P < 0.05 versus MI
**
P < 0.01 versus MI.
Data are expressed as mean ± SEM.
MI, myocardial infarction; Scu, scutellarin; EF, eject fraction; FS, fractional shortening; LVDd, left ventricle diastolic diameter; LVSd, left ventricle systolic diameter.