Table 3.

Multivariable Model for Survival After Brain Metastases (n=176)

Characteristics	HR	Lower 95% CI	Upper 95% CI	P
HER-2 positive vs hormone positive/HER-2 negative	0.63	0.42	0.94	.02
Triple negative vs hormone positive/HER-2 negative	0.87	0.55	1.37	.54
Stage I/II/III vs stage IV	2.50	1.24	5.04	.01
WBRT alone vs WBRT and surgery or radiosurgery	0.67	0.40	1.13	.13
No. of positive lymph nodes (>10 vs <10)	1.99	1.15	3.42	.01
Black race vs white/other	1.41	0.85	2.34	.18
RPA class III vs RPA class I/II	3.47	2.35	5.14	<.001
Radiation dose (<30 vs ≥30 Gy)	3.41	1.56	7.50	.002

HR indicates hazard ratio; CI, confidence interval; WBRT, whole brain radiotherapy; RPA, recursive partitioning analysis; Gy, grays.