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The calibration plot for the ratio of the ion-currents at m/z 168 (8-OH-dGuo) and m/z 170 (8-OH-dGuo-18O) versus the ratio of the molar amounts of 8-OH-dGuo and 8-OH-dGuo-18O. All values represent the average (± standard deviation) of three independent measurements. For these measurements, the injected amounts of 8-OH-dGuo and 8-OH-dGuo-18O varied from 0.1 and 0.28 nmol (ratio = 0.357), respectively, to 0.45 and 0.04 nmol (ratio = 11.25), respectively.
