Table 3.
Top 10 Choke point enzymes in P. aeruginosa ranked by number of shortest paths.
| Enzyme Id | Enzyme Name | Gene Ids | Load value (in) | Load value (out) | k-Shortest paths (in) | k-Shortest paths (out) | Human choke point | Top BLAST hit (identity) (%) |
|---|---|---|---|---|---|---|---|---|
| 2.4.2.7* | Adenine phosphoribosyl transferase | PA1543 | 1.11 | 1.89 | 74459 | 74459 | No | NoHomologue |
| 2.4.2.8 | Hypoxanthine phosphoribosyl transferase | PA4645 | 0.85 | 1.52 | 60639 | 60639 | Yes | 26% |
| 2.7.4.6 | Nucleoside-diphosphate kinase | PA3807 | 1.47 | 1.17 | 55297 | 55297 | Yes | 48% |
| 2.7.4.14 | Cytidylate kinase | PA3163 | 1.37 | 1.59 | 50169 | 50169 | No | NoHomologue |
| 6.2.1.1* | Acetate-CoAligase | PA0887 PA1997 PA2555 PA4733 |
−0.03 | −0.16 | 48355 | 48355 | No | NoHomologue |
| 2.6.1.1 | Aspartatetransaminase | PA2828 PA3798 PA4722 PA4976 |
0.54 | 0.34 | 40463 | 40463 | Yes | 33% |
| 2.2.1.1 | Transketolase | PA0548 | 1.36 | 1.46 | 40019 | 40019 | Yes | 26% |
| 4.2.1.11 | Phosphopyruvate hydratase | PA3635 | 2.28 | 2.07 | 38260 | 38260 | Yes | 54% |
| 3.6.1.7* | Acylphosphatase | PA0954 | 4.07 | 1.87 | 28547 | 28547 | No | NoHomologue |
| 6.3.5.4* | Asparagine synthase (glutamine-hydrolysing) | PA0051 PA2084 PA3459 |
0.03 | −0.05 | 25142 | 25142 | No | NoHomologue |
*
Choke point enzymes reported as potential drug targets in the common pathways shared between the pathogen and human.