Figure 2. HIV depletes αβ T-cell clones and, despite increasing cell numbers during treatment, these clones and their functional responses are not recovered.

The redundancy of Vγ2Vδ2 T cells absorbs the initial impacts of HIV. When cell members are recovered during treatment, normal function also returns. Clonal depletion occurs in both types of T cell, but the impact on function is less for the Vγ2Vδ2 subset.