Effect of MMP-12 inhibition on atherosclerotic plaque area. A, Elastic van Gieson–stained brachiocephalic artery, aortic root, and proximal aorta atherosclerotic lesions. B to E, Quantification of brachiocephalic artery (B), aortic root (C), proximal aorta (D), and thoracic aorta (E) plaque cross-sectional area, from control and RXP470.1-treated mice (*P<0.05). Scale bar in panel i (A) represents 100 μm and is applicable to i, ii, v, and vi. Scale bar in iii represents 200 μm and is applicable to iii and iv.