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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2011 Jan 6;31(3):528–535. doi: 10.1161/ATVBAHA.110.219147

Figure 4.

Figure 4

Effect of MMP-12 inhibition on brachiocephalic atherosclerotic plaque composition. A, Identification of buried fibrous layers (arrows) from control and RXP470.1-treated mice. SMC indicates smooth muscle cell. B, Presence of calcification (brown/black, arrows) in brachiocephalic artery lesions from control and RXP470.1-treated mice. Quantification is summarized in the adjoining graphs and depicts mean±SEM (*P<0.05, n≥23 per group). Scale bars represent 100 μm and are applicable to all panels.