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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2011 Jan 6;31(3):528–535. doi: 10.1161/ATVBAHA.110.219147

Figure 6.

Figure 6

Effect of MMP-12 gene deletion on apoptosis and calcification. A, Necrotic core area of brachiocephalic artery lesions from apoEKO/MMP-12WT and apoE/MMP-12DKO mice. SMC indicates smooth muscle cell. B, Immunohistochemical labeling of brachiocephalic artery lesions for macrophages, smooth muscle cells (both red) and apoptosis (brown, arrows). C, Presence of calcification (brown/black, arrows) in brachiocephalic artery lesions from apoEKO/MMP-12WT and apoE/MMP-12DKO mice. Quantification is summarized in the adjoining graphs and depicts mean±SEM (*P<0.05, n≥23 per group). Scale bars represent 100 μm and are applicable to adjoining panels.