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The distinct recognition mechanisms of MTX toward the IKCa and Kv.1.2 channels. (A), (C) Interaction details of Tyr32 and Lys7 of MTX in the MTX-IKCa complex within a contact distance of 5Å, respectively. (B), (D) Interaction details of Tyr32 and Lys7 of MTX in the MTX-Kv1.2 complex within a contact distance of 5Å, respectively.
