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Interleukin-6 (A) and TNF-α (B) immunostaining of islets of Langerhans (original magnification 400×) in ZDF rats. (A1 and B1) - Staining of the islet of a 20-wk-old sedentary diabetic (fa/fa) rat showing high immunostaining (+++); (A2 and B2) - Staining of the islet of a 20-wk-old exercised diabetic (fa/fa) rat with a significant reduction in the expression of interleukin-6 (A) and TNF-α (B) immunoreactivity (+).IL-6, interleukin 6; TNF-α, tumour necrosis factor α. Adapted from [34]).
