Comparison of sleep parameters during baseline, 1-h S-DEP and 3-h S-DEP. A, C, E contain data from saline-treated mice; B, D, F contain data from minocycline-treated mice. Repeated measures ANOVA with pharmacological treatment as a grouping factor and S-DEP duration (0, 1, 3) and time of day as repeating factors yielded significant main effect of S-DEP on all parameters, but no S-DEP × pharmacological treatment interactions. The timing of the light/dark cycle is indicated by the white and dark bars at the top of the each graph.