Figure 3. Demyelination in T cells-knockout mice.

CD4^−/− and CD8^−/− mice were infected ocularly with HSV-IL-2 or HSV-IL-4 as described in Materials and Methods. After 14 days, ON, SC, and brains were removed, sectioned, and stained for LFB. Arrows indicate areas of demyelination in ON, SC, and brain of HSV-IL-2 infected mice.