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. 2011 Feb 18;6(2):e16052. doi: 10.1371/journal.pone.0016052

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Mostowy et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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In both panels the time of emergence of mutants with a given number of escape mutations is shown. Orange and blue bars correspond to runs with and without recombination, respectively. A shows the time of appearance of E escapes (escapes at the escape locus). Panel B shows the time of appearance of EC escapes (escapes at the escape and compensatory locus). The simulations show that recombination accelerates the emergence of escape mutations. Parameters used: , ; the others are defined in Table 1. The plot shows an average of 10000 simulation runs.

Inline graphic — In both panels the time of emergence of mutants with a given number of escape mutations is shown. Orange and blue bars correspond to runs with and without recombination, respectively. A shows the time of appearance of E escapes (escapes at the escape locus). Panel B shows the time of appearance of EC escapes (escapes at the escape and compensatory locus). The simulations show that recombination accelerates the emergence of escape mutations. Parameters used: , ; the others are defined in Table 1. The plot shows an average of 10000 simulation runs.